MicroRNAs And Epigenetics In Alzheimer’s Disease: Study From The Whole Human Genome | 39042
Journal of Biotechnology & Biomaterials
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Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease throughout the world. Most of the clinical
symptoms of AD appear at a very later stage, therefore, the identification of disease markers is essential which can help
proper detection of AD at an earlier stage and slow down its progression. Small non-coding RNAs, microRNAs (miRNAs), are
modulators of gene expressions and play important roles in cellular processes. Recent studies implicate certain miRNAs in the
pathogenesis of AD. Epigenetic markers such as DNA methylation and histone modification around promoter regions modify
chromatin structure and regulate expression of downstream genes. Epigenetic studies have also revealed that miRNAs are
directly regulated by DNA methylation and histone modification at their promoters as well. In this work, we have performed a
genome wide study to reveal the distribution of AD related proteins (AD_R) and proteins previously not known to be associated
with AD (AD_UR) from the human genome. We have constructed regulatory networks involving genes, transcription factors
and miRNAs. Several network motifs namely feed forward loop (FFL), feed-back loop (FBL) and single input module (SIM)
were studied from the regulatory networks. We have identified the epigenetic modification patterns of regulators of these
network motifs. Our study also revealed the long non-coding RNA and other non-coding RNA mediated regulations in AD.
AD biomarkers and epigenetic modifications identified in our study will provide insight into new AD therapeutic targets.
Debjani Roy has completed her PhD in Computational Biology from New York University, USA. She is currently an Assistant Professor at Biophysics Department, Bose Institute, Kolkata. Her research interests include computational systems biology, drug repositioning and structural bioinformatics. She has so far published more than 30 papers in reputed journals and has presented her work in many national and international conferences.