ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 2154

Journal of Biotechnology & Biomaterials received 2154 citations as per Google Scholar report

Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • ResearchBible
  • China National Knowledge Infrastructure (CNKI)
  • Access to Global Online Research in Agriculture (AGORA)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • ICMJE
Recommended Journals
Share This Page

Molecular imaging of cancer with core/shell nanoparticles

5th World Congress on Biotechnology

Boguslaw Tomanek

ScientificTracks Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.S1.027

Abstract
Standard clinical MRI often fails to detect cancer in its early development stages. Therefore application of molecular sensing would ensure earlier and more accurate diagnosis. To increase MRI sensitivity contrast agents containing gadolinium are used, providing hyperintense T1-weighted tumor MR image. Superparamagnetic nanoparticles have recently been used to reduce T2 and T2*, thus decreasing MR signal in areas corresponding to the location of the disease. Accumulation of these contrast agents is solely based on differences in the vasculature of tumor and normal tissues, and MRI detection of specific tumor types is not achieved. We investigated magnetic and biochemical properties of iron oxide core and core/shell nanoparticles for breast and glioma cancers. Triple negative breast cancer and glioma specific sdAb were conjugated with nanoparticles and IR markers using amine-functionalized coating. The IR and T2-weighted MR images were collected before and after injection of the targeted contrast agent. The agents consist of targeted NaDyF4/NaGdF4 nanoparticles, where the core and shell sizes were controlled independently to provide maximum tumor contrast by application of synergetic T1/T2 MR pulse sequences. This allows better tumor delineation and positive, tumor-specific contrast. A 9.4T MRI system was used to measure relaxation time values of the tumor and normal tissue. Using IR and MRI we have shown the efficacy of the new contrast agents, thus potential suitability for the early detection of cancerous tissues.
Biography
Boguslaw Tomanek,following the completion of his PhD at the Polish Academy of Sciences Krakow, Poland in 1995 joined the National Research Council of Canada. In 2000 he became the head of the MR Technology group. In 2001 he established the Institute for Biodiagnostics (West) in Calgary, Canada. He led the team who created the first intraoperative MRI system; discovered a new mechanism of fMRI and gradient-free MRI. He has published over 100 publications, several book chapters; he is a reviewer for various journals and a recipient of several achievement awards. His current area of interest is molecular MR imaging.
Top