Myeloid-derived Suppressor Cells As A Potential Therapeutic Target For Women With Early Miscarriage | 40686
Journal of Biotechnology & Biomaterials
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The etiologies of first trimester loss are multifactorial and often remain unknown, certain risk factors increase the likelihood
of pregnancy loss. To date there are many factors known to cause EPL but due to very heterogeneous condition of EPL or
RPL, it still remains unresolved and unexplained. The identification of the underlying causes of pregnancy loss is important
for developing more successful treatments for women experiencing RPL and thereby preventing subsequent pregnancy
loss. A multitude of immunomodulatory properties of the fetal-maternal interface have evolved to allow the survival of the
immunologically distinct fetus without an attack from the maternal immune system. To identify the contribution of inflammatory
molecule we studied the level of S100A8 the inflammatory protein and MDSCs the cells regulating its expression in pregnancy
loss patients. The contribution of S100A8 and myeloid-derived suppressor cells (MDSC) in patients suffering from early or
recurrent miscarriage is unknown. S100A8 is a calcium binding proteins and is found at high levels in the extracellular milieu
during inflammatory conditions. MDSC are implicated in modulation of T-cell response in healthy pregnancies: However,
the role of MDSC in patients suffering from miscarriage has not been studied. S100A8 level was analyzed by real time PCR,
Western Blotting and ELISA. MDSC level was assessed by flow Cytometry and Immunostaining in blood and endometrial
decidua respectively. Activation of T-cells was determined by MTT proliferation and IL-2 ELISA assays. The miscarriage
patients harbor increased level of S100A8 and reduced level of functionally suppressive MDSC in blood and endometrium as
compared to healthy control women with successful pregnancies. These results suggest S100A8 and MDSC are inversely corelated.
MDSC level regulates maternal tolerance in healthy pregnancies and that drug inducing MDSC could have therapeutic
implication in the miscarriage patients.
Rohini Ravindran Nair has completed his PhD from Banaras Hindu University. She has received Marie-Curie CO-INVEST Fellowship. She is at present working as a Postdoctoral Fellow in San Raffaele Scientific Institute, Italy. She has published 14 papers in reputed journals and a book chapter.