alexa Nanogels Preparation For Controlled Bioactives Delivery | 63874
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd Annual Conference and Expo on BIOMATERIALS

Iordana Neamtu, Loredana E Nita, Aurica P Chiriac, Alina G Rusu, Alina Diaconu, Nita Tudorachi and Liliana Mititelu Tartau
Petru Poni Institute of Macromolecular Chemistry, Romania
Posters & Accepted Abstracts: J Biotechnol Biomater
DOI: 10.4172/2155-952X.C1.074
Abstract
Nanogels are cross-linked polymeric particles, which can be considered as hydrogels if they are composed of water soluble/ swellable polymer chains. Their applications for polymer-based bioactives’ delivery systems require biodegradability, controlled particle size with uniform diameter, large surface areas for multivalent bioconjugation and interior network for the incorporation of different therapeutics, environmental-stimuli responsive capability, dispersibility in biological fluids, sustained release in time of bioactives and facile removal of the devices after the bioactives delivery, etc. This study describes the synthesis and characterization of a stimuli-responsive nanogel performed by crosslinking poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5] undecane) with 1,12 dodecandiol. The copolymer with different ratios between the two comonomers is able for network formation, binding properties, amphilicity, and good oxidative and thermal stability. At the same time the new nanogel structure has high functionality, biocompatibility, temperature and pH responsivity, and is designed to have potential biomedical applications. The chemical structure is explored utilizing common spectroscopic analyses, while the dual pH and temperature sensitivity is evaluated by determining the hydrodynamic radius and zeta potential by dynamic light scattering technique. The analysis of the thermal stability by thermogravimetric analysis supports the new covalent bonds realized by the crosslinking reaction between the copolymer and diol. The acute toxicity of the nanogel is estimated after mice oral administration. Accordingly, analysis of histological evaluation of liver tissues does not reveal substantial pathological modifications. The results propose that the nanogel may be suitable for in vivo use as bioactives’ delivery system.
Biography

Iordana Neamtu is a Senior Scientific Researcher at “Petru Poni” Institute of Macromolecular Chemistry in Iasi - Romania. Her expertise is in synthesis of polymer materials with potential biomedical applications. She has published more than 50 papers in reputed journals and participated in more than 15 Romanian Projects.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7