alexa
Reach Us +1-947-333-4405

GET THE APP

Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Natural Products Research: A Potential Source Of Innovative New Drug Discovery And Development | 105438
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences
Google Scholar citation report
Citations : 1224

Journal of Infectious Diseases & Therapy received 1224 citations as per Google Scholar report

Indexed In
  • Index Copernicus
  • Google Scholar
  • Open J Gate
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • Publons
  • Euro Pub
Share This Page

Natural products research: A potential source of innovative new drug discovery and development

Global Experts Meeting on Infectious Diseases, Diabetes and Endocrinology

Festus M Tolo and Charles N Muthaura

Kenya Medical Research Institute, KenyaUniversity of Nairobi Institute of Tropical Medicine and Infectious Diseases, Kenya

ScientificTracks Abstracts: J Infect Dis Ther

DOI: 10.4172/2332-0877-C2-062

Abstract
Enabling innovation and access to health technologies remains a key strategy in combating infectious diseases in low and middle income countries. In such countries, infectious disease are a leading cause of death and are difficult to control if the infectious agents evolve resistance to commonly used drugs. Modern medicine needs new kinds of antibiotics and antivirals to treat drug-resistant infections. One source of such drugs lies in medicinal plants, an available resource still abundant in Africa. Both herbal and traditional medicines of plant origin have provided templates that have served as scaffolds for rational drug design. We have presented a new management therapy being developed for herpes infection in human from a medicinal plant with activity for both acyclovir resistant and sensitive strains of Herpes Simplex Virus. Herpes is a viral infection affecting over 60% of the Sub-Saharan Africa young adult population. The herbal product, Zedupex has been evaluated for preclinical safety and efficacy in suitable in vitro and in vivo systems of herpes infections. Cytotoxic concentrations of the product in mammalian cell lines have indicated a wide therapeutic index (CC50???58.54.6 ?g/ml). In vivo, an EC50 of ???14.73.7 ?g/ml for both wild type and resistant strains of HSV has been realized in plaque and viral yield assays. Oral (250 mg/kg) and topical (10% cream) administrations exhibits a significant delay in onset of infections, hindered progression of infection to lethal forms with increased mean survival times and low mortality with no acute toxicity at therapeutic concentrations. Financial constrains has slowed down the progression of clinical trial stages in human of this product but results so far obtained exemplify the potential that still exists from medicinal plants.
Biography

Festus M Tolo is a Medicinal Phytobiologist holding a PhD in Medicinal Phytochemistry, a fellow at the African Scientific Institute and an awardee of the “The Nelon Gold Award (NGA)” of the Kenya Medical Research Institute (KEMRI). He also holds the Inter-Academy Medical Panel “Distinguished Scientist Award” of the Chinese Medical Sciences (CACMS) and Chinese Academy of Engineering (CAE) in Natural Products Research. Tolo is a Chief Research Officer and the Head of the Natural Products Research and Drug Development Programme (NAPREDA) at KEMRI.

E-mail: [email protected]

 

Top