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Erinacine A, the main representative of erinacines existed only in the Hericium erinaceum mycelium, was found to induce
nerve growth factor (NGF) synthesis in vitro, and was proved could cross the blood?brain barrier in vivo. Other studies
showed this compound also increased catecholamine and NGF content in the central nervous system of rats. In this study, we
investigated the production of erinacine A in 20T fermenter and its identification by use of LC-MS-MS and NMR. Purified
erinacine A and mycelium extracts were used to treat PC12 cell line for evaluating neural differentiation. Our results showed
that erinacine A induced neural differentiation of PC12 cells in a dose dependent manner. In an in vitro study, we examined
the effects of erinacine A on amyloid ?-peptide (25-35) induced neurotoxicity in primary cortical neurons. In our in vivo data
demonstrated induced neurogenesis by erinacine A in transgenic (APP/PS1) mice. We then investigated the neuroprotective
effects of H. erinaceum in a MCAO and Parkinson?s model in rat. Results showed infarct volumes markedly reduced in rat
receiving 300 mg/kg H. erinaceum treatment for 5 days prior to 1.5 hr MCAO. Oral treatment of H. erinaceumdry mycelium
powder (300 mg/kg) in Parkinson?s disease rats showed increased brain dopamine and tyrosine hydroxylase content. H.
erinaceum safety assessment showed no treatment related toxicity in rat garaged up to 3000 mg/kg for 28 consecutive days.
Chin-Chu Chen received his PhD degree in toxicology and bioactivity at National Tsing Hua University in Taiwan. His primary field is industrial liquid fermentation of
mushroom mycelium such as Ganoderma lucidum, Cordyceps and Antrodia cinnamomea and uses these ingredients to develop health foods. His group had 19 patents
and published more than 25 papers in reputed journals. He is currently the vice general manager of Grape king Bioand head of Bioengineering Center. He served for
professional professor in Hung-Kuang University and Associate Professor in Shin-Chien University, National Hsinchu University, National Changhua University, Chung-
Yuan Christian University and Yuanpei University.
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