alexa Novel Quinolone Derivatives Compound (NQDC) Induced Autophagic And Apoptotic Cell Death In 5FUresistant HT29 Cells
ISSN: 2476-2067

Toxicology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th World Congress on Toxicology and Pharmacology
April 13-15, 2017 Dubai, UAE

Jai-Sing Yang
China Medical University, Taiwan
Posters & Accepted Abstracts: Toxicol Open Access
DOI: 10.4172/2476-2067.C1.003
Abstract
In this study, novel quinolone derivatives compound (NQDC) suppressed viability in 5FU-resistant HT29 cells through inhibiting cell proliferation, causing cell cycle arrest and triggering apoptosis. In this study, we investigated the oral anticancer activity of NQDC and its mechanism in 5FU-resistant human colon cancer cells. Our results demonstrated that NQDC had an extremely low toxicity in normal oral cells and provoked autophagic cell death to form AVOs and autophagic vacuoles in 5FU-resistant HT29 cells by AO and MDC staining. DNA fragmentation and condensation occurred in NQDC-triggered 5FU-resistant HT29 cell apoptosis. Colorimetric assay analyses also showed that activities of caspase-3 and caspase-9 occurred in NQDC-treated 5FU-resistant HT29 cells. Overall, our findings indicate that NQDC is likely to induce autophagic and apoptotic death in 5FU-resistant HT29 cells.
Biography

Jai-Sing Yang is a Research Fellow at Department of Medical Research, China Medical University Hospital, China Medical University, Taiwan. His main research interests include exploring molecular mechanisms of herbal medicine and new drugs against cancer development. He has set up the research platform, mainly combining molecular pharmacology, immuno-pharmacology, cell biology, drug delivery, nano-technology, animal models and bio-informatics for screening anticancer activities of herbal products or newly synthetic drugs. He focuses his work on the development of natural products, traditional Chinese medicine (TCM), drug-loaded nanoparticles and the synthesis of new compounds against different types of cancers.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmental[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords