Novel Resorbable And Osteoconductive Nurse’A Phase-silicocarnotite Scaffold Induced Bone Formation | 63870
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

2nd International Conference on Biotechnology and Healthcare

Auckland, New Zealand
Google scholar citation report
Citations : 1536

Journal of Biotechnology & Biomaterials received 1536 citations as per google scholar report

Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • ResearchBible
  • China National Knowledge Infrastructure (CNKI)
  • Access to Global Online Research in Agriculture (AGORA)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Novel resorbable and osteoconductive nurse’A phase-silicocarnotite scaffold induced bone formation

2nd Annual Conference and Expo on BIOMATERIALS

Mazon P, Ros-Tarraga P, Meseguer-Olmo L, Rodriguez M A, and De Aza P N

Universidad Católica San Antonio de Murcia, Spain Instituto de Cerámica y Vidrio, Spain Universidad Miguel Hernández Avda, Spain Universidad Miguel Hernández, Spain

Posters & Accepted Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.C1.074

Alternatives to natural bone grafts are needed in a society that progressively prolonged life expectancy, and it should address the health problems of an aging population. In this context calcium silicophosphate scaffolds are promising candidates. Composition belongs to subsystem Nurse’s A-phase-Silicocarnotite was selected for the ceramic scaffolds that were prepared by the polymer replication method. An interconnected porous structure with a striking similarity to human cancellous bone tissue was obtained. Response to ceramic scaffolds was evaluated by implantation in New Zealand tibia rabbits in periods of 3 and 6 months. Radiological studies showed correct integration and partial resorption of the scaffold. Histological results presented no evidence for inflammation or infection at the implantation sites. Colonization process of the scaffold started in the periphery and then penetrated throughout implant porosity. Scaffolds degraded over time and that degradation happened according to the tissue in-growth rate. Histomorphometric analysis gave high BIC values (67.30% ± 1.41) opposite to control samples, where newly formed bone in the cortical defect increased in a smaller amount than in the grafted defects. After six months of implantation SEM studies reveal that the whole ceramic implant surface was covered by a newly formed bone tissue. The new bone layer was composed of Ca-P, mainly with traces of Si due to the gradual diffusion of Si ions from the scaffolds into the newly forming bone, which formed part of the biomaterial’s resorption process. The results indicate that this material provides an optimal microenvironment for the osteogenic differentiation of the undifferentiated osteoblastic precursor cells contained in hematopoietic bone marrow.

Patricia Mazón studied Chemistry at the University of Alicante, and pursued her PhD about aminoacids synthesis. She started her adventure in Biomaterials field in 2012 at the University Miguel Hernández. Currently, she is a Professor at the Department of Materials Science, Optic and Electronic Technology and Researcher at the Biomaterials area of Bioengineering Institute.

Email: [email protected]