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Permacol™ Collagen Paste Injection In Anal Fistula Treatment: Retrospective Study With Eighteen Months Follow-up | 104986
ISSN: 2155-952X
Journal of Biotechnology & Biomaterials
Open Access
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Introduction: This study aimed to evaluate the applicability, safety, results, and functional performance of Permacol™ collagen
paste injection in patients with an anal fistula.
Methods: Thirty-nine patients with anal fistula underwent Permacol™ collagen paste injection between February 2015 and
February 2018. The patients were followed up for a total of 18months with intervals of 3, 6, 12 and 18 month recovery conditions
monitored. Fifteen patients for a period of 6-8 weeks and two patients for a period of 12 weeks underwent preoperative
insertion of seton.
Results: A transsphincteric anal fistula was present in 20 patients, and an intersphincteric fistula was present in 11 patients.
There was a recurrence in 7 patients (17.9%): 1 patient (2.5%) after 1-month follow-up, 3 patients (7.6%) after 3-month
follow-up, 2 patients (5.1%) after 6-month follow-up, and 1 patient (2.5%) after 18-month follow-up. A complete recovery
was observed in 32(82.0%) patients after a 18-month follow-up. The mean Fecal Incontinence Severity Index (FISI) score was
0.29 �0.64 preoperatively and 0.55 �1.03 after 12 months.
Conclusion: In this study, we show that Permacol??? is a safe and successful method that does not compromise continence
following injection and treatment of patients with an anal fistula.
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4. Giordano P, Sileri P, Buntzen S, Stuto A, Nunoo-Mensah J, Lenisa L, et al., Final results of a European, multi-centre,
prospective, observational Study of Permacol() collagen paste injection for the treatment of anal fistula. Colorectal Dis.
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5. Giordano P, Sileri P, Buntzen S, Stuto A, Nunoo-Mensah J, Lenisa L, et al., A prospective multicentre observational study
of Permacol collagen paste for anorectal fistula: preliminary results. Colorectal Dis. 2016;18(3):286-94.
Biography
Mehmet Bayrak and Yasemin Altıntas have expertise in evaluation and passion in improving the health and wellbeing. Their open and contextual evaluation model based on responsive constructivists creates new pathways for improving healthcare. They have built this treatment model after years of experience in research, evaluation, teaching and administration both in hospital and education institutions. This approach is responsive to all stakeholders and has a different way of focusing.