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Physical And Biological Characterization Of Magnetic Responsive Hydroxyapatite Nanocrystals Aimed At Bone Applications | 41679
ISSN: 2155-952X
Journal of Biotechnology & Biomaterials
Open Access
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Synthetic hydroxyapatite nanocrystals (n-HA) can be tailored to have physicochemical properties suitable for natural bone
substitutions. Similarly, magnetic nanoparticles (MNPs) are being given a growing attention because of their therapeutic
potentialities in anticancer hyperthermic treatment. Bearing this in mind, we intended to investigate MNPs-decorated n-HA
as putative agents against malignant bone disease. The goal of this study is, in fact, to provide magnetic responsiveness to bonemimicking
n-HA. To this aim, dextran-grafted magnetite nanoparticles (DM) have been prepared by an easy and scalable
synthesis based on a previously reported method1. Then, magnetic nano-architectures based on n-HA decorated by DM
nanoparticles (DM-HA) have been synthesized by an aqueous precipitation technique in the presence of different amounts
of DM (i.e., DM-HA weight ratio: 1/1, 2/1, 3/1). For each DM-HA ratio X-Ray diffraction patterns are consistent with singlephase
low crystalline HA similar to deproteinized bone apatite. Magnetic susceptibility of DM-HA shows modulation of the
magnetization as a function of the DM content. Cytocompatibility parameters of DM-HA were assessed by using a bone
derived human cell line. Morphological and physical interactions between DM-HA and cells were evaluated and compared
to DM and n-HA alone. Nanoparticles internalization was investigated by analyzing the intracellular iron content, via atomic
emission spectroscopy. Finally, the effects of DM-HA were analyzed in terms of changes in gene expression of adhesion,
proliferation and morphology markers, to identify possible interplay with physiological cells responses. Overall, we developed
the synthesis of DM-HA particles as bone substitute and anticancer materials due to their magnetic properties.