alexa Phytotherapy From Mentha Piperita L. Modulates Infection During Experimental Schistosomiasis
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

6th Euro-Global Conference on Infectious Diseases
September 07-09, 2017 | Paris, France

Fernanda F Anibal, Karina A Feitosa, MaurĂ­cio G Zaia, Silmara M Allegretti, Edson G Soares and Ana Afonso
UFSCar, Brazil
UNICAMP, Brazil
FMRP-USP, Brazil
IHMT, Portugal
ScientificTracks Abstracts: J Infect Dis Ther
DOI: 10.4172/2332-0877-C1-032
Abstract
Schistosomiasis is a chronic parasitic disease promoted by the parasite of the genus Schistosoma, and Praziquantel (PZQ) is the only drug recommended by the World Health Organization, but there are reports of resistance, suggesting the importance of studying new compounds to treat this disease. In this work, we investigate the immunomodulatory and antiparasitic effects of Mentaliv (Apsen), from Mentha piperita L. during murine infection by S. mansoni (Sm). Experimental groups: Balb/c females, C, uninfected, SM, infected without treatment, Mentha 15 (50 mg/kg) infected with Sm (80 cercariae/animal), Mentha 60 (50 mg/kg), infected and treated daily for 60 days and PZQ, infected and treated with single dose (400 mg/kg) at the 43rd day after infection. The cell profile in the blood and serum IL-4 and IL-10 cytokines were analyzed. And the antiparasitic effect on egg count in the liver, intestine and granulomas, and comet assay for DNA modifications in worms recovered after treatments. Mentaliv phytotherapy has immunomodulatory and antiparasitic effects during murine infection of experimental schistosomiasis, by reducing serum levels of IL-4 and IL-10, and indirectly modulating negatively the blood eosinophils in the Mentha 60 group. In addition, there is an antiparasitic effect in these animals of the Mentha 60 group where there is a reduction in the number of eggs in the liver, intestine and in the hepatic granulomas. However, the absence of the genotoxic effect on Sm, suggests that other structures of the parasite other than DNA are being altered and thus contributing to the reduction of parasitic load. Thus, it is suggested that menthol and menton may be the main components of Mentha piperita L. with antiparasitic effect in this model.
Biography

Fernanda F Anibal has completed her PhD from University of São Paulo, Brazil in Basic and Applied Immunology. She is a Principal Investigator at Laboratory of Inflammation and Infectious Diseases (Federal University of São Carlos) seeks new tools for the treatment, prevention and diagnostics for infectious diseases. Currently, they are working with two plants and six enzymes and their effects against Schistosomiasis mansoni, leishmaniasis and toxocariasis, about the treatment of the infectious diseases. Their group studies effects of plants (extracts) and their isolated fractions to evaluate the anti-parasitic and anti- inflammatory effects and for infectious disease prevention, moreover have been working on the evaluation of the proteins of the parasite that has been potential to induce immune responses that decrease the parasite burden.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords