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Pitfalls To Beware In In Vitro Release Studies | 38992
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

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Pitfalls to beware in in vitro release studies

6th World Congress on Biotechnology

Maneesha Pande and Ashok N Bhaskarwar

Indian Institute of Technology, Delhi, India

ScientificTracks Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.C1.043

In vitro drug release study is an important procedure that is employed by researchers to assess whether the formulation developed by them and or the processing carried out with respect to the active medicinal components are capable of releasing the drug in sufficient quantities and over a desired time period. This study also serves as a tool to compare different formulations. The official compendia give elaborate protocols for the test which is mandatory for all approved and marketed pharmaceutical products. At the research level, however, as the research formulations are usually un-conventional, the apparatus and procedures followed for this study are tailor-made to adapt to the specific formulation under examination. It is therefore important that all factors and parameters that can affect the drug release specifically those that affect mass-transfer are carefully addressed during the development of the protocols. The present work shows how one such parameter- the dialysis membrane commonly used to retain the drug formulation can adversely affect the release of the drug enclosed within it and give erroneous results with respect to the release of the drug. Other factors and parameters which are extremely important and therefore should be given due consideration have also been discussed.

Maneesha Pande has a Master’s degree in Pharmaceutics and Pharmaceutical Technology from Gujarat University, India. She has about 12 years of industrial and teaching experience and is presently pursuing Doctoral studies at the Indian Institute of Technology Delhi, India.

Email: [email protected] [email protected]