alexa Polyphenol Resveratrol Triggers Cisplatin-resistant Human Oral Cancer CAR Cell Autophagy And Apoptosis
ISSN: 2476-2067

Toxicology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th World Congress on Toxicology and Pharmacology
April 13-15, 2017 Dubai, UAE

Chi-Cheng Lu, Chao-Hsiang Chang and Jai-Sing Yang
China Medical University, Taiwan
Posters & Accepted Abstracts: Toxicol Open Access
DOI: 10.4172/2476-2067.C1.003
Abstract
Resveratrol is known to be an effective chemopreventive agent against multiple tumor cells, but the increasing drug resistance avoids the cancer treatment in oral cavity cancer. In the current study, we investigated the oral anti-tumor activity of resveratrol and its underlying mechanism in Cisplatin-resistant oral cancer CAR cells. Our results demonstrated that resveratrol provoked autophagic cell death to form AVOs and autophagic vacuoles in CAR cells by acridine orange (AO) and monodansylcadaverine (MDC) staining. Inhibitors of PI3K class III (3-MA) and AMP-activated protein kinase (AMPK) (compound c) suppressed the autophagic vesicle formation, LC3-II protein levels and autophagy induced by resveratrol. Z-VAD-FMK (pan-caspase inhibitor) attenuated resveratrol-triggered cleaved caspase-9, cleaved caspase-3 and cell apoptosis. Resveratrol also enhanced phosphorylation of AMPK and regulated autophagy- and pro-apoptosis-related signals in resveratrol-treated CAR cells. Our results indicated that resveratrol is likely to induce autophagic and apoptotic death in drugresistant oral cancer cells and might become a new approach for oral cancer treatment in the near future.
Biography

Chi-Cheng Lu completed his Graduation and Doctorate from National Chung Hsing University (NCHU), Taichung, Taiwan. He worked at the Department of Food Science and Biotechnology of NCHU as a Post-doctoral Fellow under Chair Professor Gow-Chin Yen. He then worked with Research Fellow Dr Jai-Sing Yang of China Medical University Hospital (Taiwan) as a Post-doctoral Research and Project Scientist. His specific interests are focused on targeting tumor cell demise (apoptosis, autophagy and necrosis) and anti-metastatic effect in vitro and in vivo after exposure to phytochemicals and the synthesis of novel compounds. He has also undertaken oxidative stress and functional food research in recent years and is exploring their molecular mechanisms.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords