PPARG: A Possible Target For Type-2 Diabetes Induced Dementia | 39089
Journal of Biotechnology & Biomaterials
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Type-2 Diabetes Mellitus (T2DM) is the most complex and rising disease in the recent years. It is believed that T2DM is
associated with various diseases in which dementia is the major one. Studies have reported that diabetes increase the
risk of dementia by 1.5 to 2 fold. In the etiology of diabetes induced dementia/cognitive impairment, inflammatory markers,
disturbed immune response and increased apoptosis plays a critical role in the production of oxidative stress in the peripheral
tissues. To manage these challenges, it is required to incorporate flavonoids, terpenoids & alkaloids in our diet. This will
suppress neuroinflammation and promote memory learning and cognitive functions. In the current study, we have developed
a map that represents the progression of T2DM to dementia by using differentially expressed proteins. It was observed that
PPARG plays a crucial role in transferring T2DM to dementia. We have also docked PPARG receptor with flavonoids along
with marketed drug of T2DM for further drug designing targeting T2DM induced dementia.
Khyati Mittal has completed her MSc in Industrial Chemistry and she is currently pursuing PhD in Biotechnology in Amity University, Uttar Pradesh. Her area of specialization is Pharmaceutical Biotechnology. She has one publication in International Journal of Pharmaceutical Science Research and Review.