Rate Of Interaction Between Antibiotics And Nonsteroidal Anti-inflammatory Drugs In A District Hospital In Palestine | 64263
Toxicology: Open Access
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Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotics (ATBs) are commonly prescribed together. We
aimed to describe the rate of interaction between these two drug groups in ambulatory prescriptions made at a district hospital
Methods: In this retrospective, cross-sectional study, we analyzed a random sample of outpatient prescriptions ordered over
one year by the outpatient clinics and emergency room in Beit Jala Hospiatal, Bethlehem, Palestine. The orders which contained
a combination of NSAIDs and ATBs were analyzed for the rate and significance of drug interactions between these two drug
Results: Out of 2208 prescriptions screened, 91 orders contained a combination of NSAIDs and ATBs (4.1%) and were
included in the study. Within the included prescriptions, 45 orders harbored potential drug interactions between the two drug
groups (49.5%). Regarding the significance of these interactions, none of them was serious. However, 21 orders were rated to
have significant interactions (46.7%) while 24 prescriptions had non-significant interactions (53.3%). The most common ATB
which was found to cause significant interaction was ciprofloxacin (100%). On the other hand, aspirin was the most important
NSAID to cause significant interaction (42.8 %) followed by diclofenac (38.1%).
Conclusions: Our data revealed a remarkably high rate of drug interactions between ATBs and NSAIDs. To minimize the
potential harm as a result of this interaction, prescribers’ awareness of the importance of careful drug selection needs to be
reinforced. This should ideally include providing training for physicians on the use of free online drug interaction checkers.
Yasin I Tayem received his MD from Al-Quds University School of Medicine, Palestine in 2001 and PhD in Clinical Sciences from the University of London, United Kingdom in 2006. He was an Assistant Professor of Pharmacology at the Al-Quds University from 2006 until 2012. Then he was a Post-doctoral research fellow at the National Institutes of Health (NIH), Maryland, USA. Since, 2013 he has been an Assistant Professor of Pharmacology and Therapeutics at the Arabian Gulf University in Bahrain. He has published more than 17 articles. His research focuses on drug interactions, pharmacology education and language barrier in medical education in the Arab World.