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Regulation Of Angiogenesis By Endogenous Metabolite | 17088
Journal of Biotechnology & Biomaterials
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Choroidal neovascularisation (CNV) is the primary cause of blindness in a variety of common retinal diseases including
retinopathy of prematurity, age related macular degeneration, proliferative diabetic retinopathy, among other vascular
diseases. Angioinhibitory therapies are starting to give hopeful results in these ocular diseases. In this study the angioinhibitory
activity of endogenous metabolite derived from type IV collagen was analyzed.Mouse choroidal endothelial cells (MCEC)
treated with different doses of metabolite and performed
proliferation, migration and tube formation assays. Matrix
metalloproteinase-2 (MMP-2) activation and MMP-2/metabolite complex formation were studied using different methods.
Endogenous metabolite demonstrated anti-proliferative activity and inhibits MCEC migration, tube formation in-vitro.
Endogenous metabolite binds pro-MMP-2 and inhibits its activation mediated by both membrane-type-1 MMP and 4-amino-
phenyl mercuric acetate (APMA)
. Angioinhibitory effects of metabolite were studied in mice model using LASER-
induced CNV method.
Smita C Pawar, Assistant Professor, former Head, Department of Genetics, Osmania University, Hyderabad, India, has more than nine years of experience in
teaching, research and University administration. She is the recipient of CSIR/NET/UGC-JRF (2003) fellowship from Government of India. She worked ina reputed
national research ICMRInstitute ?National Institute of Nutrition? as Junior Research Fellow (2003-2004). She was awardedthe DST-ITS grant topresent aresearch
article in an international conference ?BDC 2010?- at Sydney,Australia. She has been awarded the Boyscast Fellowshipby DST, Government of India for the year
2011-2012. She hascompleted her post-doctoral training at University of Nebraska Medical Center,Omaha, NE USA and John Hopkins University, Baltimore, USA.
She has published more than 14 research articles in reputed international journals and is currently a research supervisor guiding students for PhD and has two
ongoing majorresearch grants funded by UGC and DBT.
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