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In Association with
Role for coronin 1 in regulating cognition and behaviour through neuronal cAMP/Protein kinase A signaling
6th World Congress on Biotechnology
Somdeb Bose Dasgupta1,2, Rajesh Jayachandran2, Xiaolong Liu2,3 and Jean Pieters2
1Banaras Hindu University(IIT), India 2University of Basel, Switzerland 3Institute of Liver Disease Research, Fujian, China
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Cognitive and behavioral disorders are thought to be a result of neuronal dysfunction but the underlying molecular defects remain largely unknown. The cAMP/Protein kinase A (PKA) pathway is known to be a key factor regulating neuronal behaviour. Genetic associations with neurobehavioral dysfunction include a chromosome region containing the gene coding for coronin 1. Our studies show that coronin 1, which was identified as a lymphocyte specific protein important for mycobacterial survival in macrophages as well as naïve T cell survival is also expressed in excitatory neurons of the brain. Interestingly, deficiency of coronin 1 results in severe behavioral abnormalities such as reduced socialization and anxiety, increased aggression and disabilities in learning. Electrophysiological studies show that coronin 1 regulates cAMP/PKA dependent synaptic plasticity at excitatory synapses. Specifically, protein kinase A-dependent cortico-lateral amygdalary long‐term potentiation was completely absent in coronin 1‐deficient mice. The coronin 1-mediated cAMP/PKA response was dependent on the stimulus dependent interaction of coronin 1 with the stimulatory G alpha subunit (Gαs). Deletion of coronin 1 or expression of coronin 1 mutants incapable of interacting with Gαs, fails to stimulate cAMP signaling. In vivo infusion of a membrane–permeable cAMP analogue, 8-Br-cAMP into coronin 1-deficient mice brain effectively rescues the synaptic and behavioral defects. Therefore, we conclude that coronin 1 regulates synaptic plasticity and neuronal behavior through its interaction with Gαs upon cell surface stimulation.Biography
Somdeb Bose Dasgupta has done his PhD in 2009, from Indian Institute of Chemical Biology, Kolkata, India and Postdoctoral studies at Biozentrum, University of Basel, Switzerland under the supervision of Prof. Jean Pieters. He has presently moved back to India as an Assistant Professor at School of Biomedical Engineering, IIT (BHU). Owing to his work on varied fields in his doctoral and post-doctoral studies, he has published several research papers. One of them lies in understanding the role of coronin 1 in cognition and behaviour and is discussed here.
Email: somdeb.bme@iitbhu.ac.in
