Journal of Biotechnology & Biomaterials
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Diabetes is a metabolic disorder of multiple aetiology. It is also a potent risk factor for cardiovascular diseases. It is characterized
by chronic hyperglycemia associated with elevated plasma free fatty acids and an enhanced generation of free radicals.
Increasing evidence suggests that this hyperglycemia is responsible for a disturbance in the production and clearance of plasma
lipoproteins leading to increasing cases of dyslipidemia in diabetics. A new way to combat heart diseases by diabetic control is
fast emerging. This experiment aimed at studying the role of including specific plant nutrients in the diet of diabetic mice to
assess the effect if any, on diabetic dyslipidemia of the experimental group. Streptozotocin (200 mg/kg/b.w) induced mice were
put on herbal diet supplements for a period extending 4 weeks following which biochemical assessment of the plasma glucose,
total cholesterol and triglycerides from the blood samples of the treatment subjected mice was done. The diabetic mice were
separated into 4 groups of 10 each and were provided with normal food and water supply. Two groups of mice were selected for
administration of aq. extract of dried rhizome powder of Curcuma longa (200mg/kg/b.w.) and aq. extract of dried fruit powder
of Emblica officinalis (200 mg/kg/b.w.) separately. To the third group a combined aq. mixture of C. longa and E. officinalis extract
in the ratio of 1:1 was administered. The fourth group was on food and water as water was the vehicle used for administration of
the plant extracts. Diabetic mice with an average fasting sugar of 335 ? 0.343, showed marked decrease in plasma glucose, total
cholesterol and triglycerides following the herbal treatment for 4 weeks. The response was, however, noticeable only towards the
middle of the second week of treatment. The response was maximum in the group receiving combination treatment and was
lesser in the group on pure C. longa extract. The group receiving only E. officinalis treatment showed the least amelioration. The
results of this experiment show that the hypoglycemic effect and hypolipidemic capacity of dietary C. longa is definitely enhanced
when supplemented with E. officinalis. These plant nutrients if necessarily incorporated into our daily diet regimen will be very
beneficial in the overall management of diabetes and related vascular damage.
Tuhin Rashmi has been a gold medalist in her undergraduate programme and has completed her Ph.D in Biochemistry from Patna University. She
is an Assistant Professor at Amity Institute of Biotechnology at Amity University Uttar Pradesh, which has been ranked as the top private university
in the country.
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