Screening For Novel Clot Busters From Food And Environmental Samples | 4719
Journal of Biotechnology & Biomaterials
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Clot busting is the breakdown or lysis of blood clots by pharmacological means and is colloquially referred to as thrombolysis.
Thrombolysis suggests the use of thrombolytic agents, which can be derived from certain microorganisms. Here we are
using Staphylococcus spp. to produce Staphylokinase (SAK), which is used to activate plasminogen. It functions by stimulating
fibrinolysis by activating plasminogen to form plasmin through the infusion of analogs of tissue plasminogen activator (tpa)
and can break up clots which may block the blood flow to the heart muscle. Staphylokinase (SAK) is a bacterial kinase produced
by certain strains of Staphylococcus spp. It is a 15.5 kDa, consisting of 136 amino acid single chain protein, which activates
plasminogen to form plasmin and digest fibrin clots. The present research work was carried out to screen the staphylokinase
producing Staphylococcus spp. from different environmental and food samples collected (milk, water and sewage) in and around
Vellore district, Tamil Nadu, India. Out of 12 isolates, 4 organisms were producing staphylokinase effectively.
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