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Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. Although there has been some progress in the usage of improved anti-inflammatory drugs, they make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system. Thus researches in screening up of anti-inflammatory components from the plants have been shown very good progress. Such similar property was been
screened using Ipomea staphylina, a local weed belonging to Convulvulaceae family. Study included the mechanism by which the Convulvulaceae species I. staphylina inhibited inflammatory pathway key enzymes. Plant extract was randomly divided into 3 groups namely water extract, ethanol extract and methanol extract. We screened by randomized trials to estimate levels of all the three key enzymes activity involved in inflammation i.e., PLA2, COX (cyclooxygenase) & LOX (lipoxygenase) using the plant sample. Results show that the water extract of the Plant sample inhibited secretory PLA2 significantly than the other groups. PLA2 was significantly inhibited as the concentration of the sample increased and this showed reproducible results. COX and LOX had inhibitory effects but not to a greater extent. These data suggest that the crude plant water extract had molecules that inhibited PLA 2 which is the first enzyme in the inflammatory pathway.
Priyadarshini K has received her Master?s degree in Bio-Technology from the University of Mysore in June 2011. She has planned to continue her
career with a PhD on her Masters Dissertation work. She worked exclusively on snake venom for the enzymatic study of secretary PLA2 action and
its inhibition using various plant samples under the world famous Venom specialist Dr. T. Veerabasappa Gowda. Other than that her oratory skills are very good. She has fantasy for Paintings and Drawings.
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