Study Of The Structure And Function Of Collagen As Determined By A Raman-tweezers Apparatus | 12214
Journal of Biotechnology & Biomaterials
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Collagen is the most abundant protein in the human body. It is the main component of the extracellular matrix as well
as connective tissues. Understanding collagen is relevant because of its role in wound and burn healing, remodeling of
the cervix during birth, engineering tissue, and collagenopathies. In order to study collagen, we have developed a Raman-
Tweezers apparatus, a powerful microscope that combines the precision of optical tweezers with the diagnostic capabilities of
Raman spectroscopy. Our ultimate goal is to employ this apparatus and develop techniquesto study the relationship between the
mechanical properties and the structure of collagen fibrils and networks. In order to determinate the elasticity of the collagen
protein arrangement, we use optical tweezers to stretch the fibril while simultaneously obtaining a Raman spectrum from a point
on the collagen fibril. Since the chemical bonds will be affected by stresses and strains applied to the fibril, we expect the Raman
spectrum to change. From our observations, we hope to learn about how this bond configuration affects the elasticity and other
mechanical properties of the fibril and of fibril networks.
Jessica Barrios Hernandez is an undergraduate, senior Applied Physics major at Appalachian State University. She has been working with Jennifer
Burris and Brooke Hester since the fall of 2012 at BiyOSeF (Bio-photonic and Optical Spectrometry Facility.) She recently received a North Carolina
Biotechnology Center-Undergraduate Biotechnology Research Fellowship for summer 2013. Jessica is expected to graduate in May 2014.
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