Study Of The Structure And Function Of Collagen As Determined By A Raman-Tweezers Apparatus | 12227
Journal of Biotechnology & Biomaterials
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Collagen is the most abundant protein in the human body. It is the main component of the extracellular matrix as well as
connective tissues. Understanding collagen is relevant because of its role in wound and burn healing, remodeling of the
cervix during birth, engineering tissue, and collagenopathies. In order to study collagen, we have developed a Raman-Tweezers
apparatus, a powerful microscope that combines the precision of optical tweezers with the diagnostic capabilities of Raman
spectroscopy. Our ultimate goal is to employ this apparatus and develop techniques to study the relationship between the
mechanical properties and the structure of collagen fibrils and networks. In order to determinate the elasticity of the collagen
protein arrangement, we use optical tweezers to stretch the fibril while simultaneously obtaining a Raman spectrum from a point
on the collagen fibril. Since the chemical bonds will be affected by stresses and strains applied to the fibril, we expect the Raman
spectrum to change. From our observations, we hope to learn about how this bond configuration affects the elasticity and other
mechanical properties of the fibril and of fibril networks.
Jessica Barrios Hernandez is an undergraduate, senior Applied Physics major at Appalachian State University. She has been working with Jennifer
Burris and Brooke Hester since the fall of 2012 at BiyOSeF (Bio-photonic and Optical Spectrometry Facility.) She recently received a North Carolina
Biotechnology Center-Undergraduate Biotechnology Research Fellowship for summer 2013.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals