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Synthesis And Solubilization Of Flurbiprofen Derivatives And Investigation Of Their Biological Activities | 63905
ISSN: 2155-952X
Journal of Biotechnology & Biomaterials
Open Access
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Flurbiprofen is one of the most potent non-steroidal anti-inflammatory drugs. It is widely used for relief of pain in patients suffering
from rheumatic diseases, migraine, sore throat and primary dysmenorrhea. However, its aqueous solubility is very low and hinders
the skin permeation. Thus, it is imperative to develop such a drug delivery systems which can improve its aqueous solubility and
hence improve the skin permeation and therapeutic compliance. Micro-emulsions have been also proven to increase the cutaneous
absorption of lipophilic drugs as compared to conventional vehicles. Micro-emulsion is thermodynamically stable emulsion that has
the capacity to ‘hide/solubilize’ water-insoluble molecules within a continuous oil phase. Therefore, flurbiprofen was converted to
esters through chemical reactions with alcohols such as methanol, ethanol, propanol and butanol. The product was further treated
with hydrazine to get hydrazide. The solubility of the parent drug flurbiprofen and the products were solubilized in micro-emulsions
formed using various surfactants like ionic, non-ionic and zwitterions. It has been concluded that the product was more soluble than
the parent compound. The biological activities of these were also investigated. The outcome was very promising and the product was
more active than the parent compound. It therefore concluded that in this way we can not only enhance the solubility of the drug,
increase its bioactivity but it also reduces the risk of stomach cancer.