alexa Tailoring Microenvironments For In Situ Regeneration
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd Annual Conference and Expo on BIOMATERIALS
March 27-28, 2017 Madrid, Spain

Elisabeth Engel, Aitor Sanchez, Miguel A Mateos, J C Rodriguez Cabello and Matilde Alonso
Institute for Bioengineering of Catalonia, Spain
CIBER-BBN, Spain
University of Valladolid, Spain
Universitat Politècnica de Catalunya, Spain
ScientificTracks Abstracts: J Biotechnol Biomater
DOI: 10.4172/2155-952X.C1.073
Abstract
At present, tissue engineering for bone regeneration seeks to obtain scaffolds that mimic the cell microenvironment to recruit stem and progenitor cells to recapitulate the development of target tissues. Herein, we have explored the use of citric acid related to bone nanostructure and mechanical performance, to develop scaffolds resembling the extracellular matrix of developing bone. Elastinlike recombinamers (ELRs) hydrogels were achieved through a one-step chemical crosslinking reaction with citric acid, a molecule currently considered to be essential for the proper performance of bone tissue. We were able to control the architecture and stiffness of citric acid-crosslinked hydrogels while preserving the integrity of adhesion sequences in ELRs. Interestingly, the use of citric acid conferred so-produced hydrogels the ability to nucleate calcium phosphate. In vivo implantation of both mechanically-tailored and non-tailored citric acid-crosslinked hydrogels demonstrated to be able to mineralize the new formed tissue and to integrate into bone in critical size defects in mouse calvaria. Both types of hydrogels showed bone tissue formation by intramembranous ossification. The non-mechanically tailored scaffold showed higher cellular activity (in terms of osteoblasts and osteoclasts presence) related to a lower density of the matrices that allowed higher cell penetration.
Biography

Elisabeth Engel is an Associate Professor at Technical University of Catalonia since 2010. She received her PhD in 2003 in Bone Metabolism Diseases from a Medical School. She was appointed as PI at the Group of Biomaterials for Regenerative Therapies since September, 2012 at the Institute for Bioengineering of Catalonia. Her research interests include the preparation and design of materials and scaffolds for in vitro and in vivo fundamental studies, and a further focus is the provision of useful tools to assess mechanisms that govern cell behaviour in regenerative medicine.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords