The Effect Of Green Tea Extracts Supplementation On Weight Changes, Serum Malondialdehyde And Blood Iron Indices In Pulmonary TB Patients: A Randomized Controlled Trial | 64931
Journal of Infectious Diseases & Therapy
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High prevalence of TB in Golestan Province in north of Iran motivated us to use supplementation with green tea extract to
promote healing. The aim of this study was to investigate the effect of green tea consumption on weight changes, iron status
and improving process of pulmonary tuberculosis treatment. This double-blinded randomized clinical trial study was conducted on
patients with TB, who were assigned randomly to the green tea group (41 patients) receiving 500 mg catechin of green tea extract and
the control group (39 subjects) receiving placebo for two months since the beginning of concomitant anti-TB treatment. Height and
weight were measured at first and two and six months thereafter. Demographic, food frequency questionnaires and 24-hour dietary
recalls of three non-consecutive days were completed. After obtaining 10 ml of venous blood, hemoglobin (Hb), transferrin, ferritin,
total iron binding capacity (TIBC), iron and serum malondialdehyde (MDA) were measured in the beginning and the end of the
study. Data were processed using independent and paired t-test, McNemar, Wilcoxon, Kaplan-Meier, Log-rank test Cox regression
model and Nutrition 4 software. At the beginning of the survey, two groups were similar according to age, gender and clinical status
(p>0.05). Average daily energy intake of patients was 1518±434 kcal, distribution of which was as follow: Carbohydrates 58%, protein
17% and fat 22%.Vitamin D and Zinc intake of patients were less and iron intake was higher than the DRI. Weight changes in both
groups of placebo and green tea had tendency of increase with a significant difference at two and six month follows ups (p˂0.0001).
However, there were no significant changes due to intervention compared to placebo. ANCOVA test showed mean difference level (P
value) in both groups for Hb, iron, TIBC, transferrin and ferritin as of: 0.004, 0.56, 0.65, 0.38 and 0.16, respectively which means that
increase of hemoglobin in the green tea group was significant compared to the placebo group. There was just a 9.2 nmol/ml difference
between the two groups for MDA in the beginning of study, which was not statistically significant (p=0.078) whereas, it was increased
to 24.8 nmol/ml after the intervention, indicating a significant difference (p<0.001). The decline value was estimated -45.45±14.69
nmol/ml for catechin group and -19.91±18.38 nmol/ml for placebo group. In conclusion, green tea as an adjuvant to TB treatment
can reduce MDA concentration and improve hematopoiesis and hemoglobin level, but no significant effect on weight gain compared
to placebo group.
Shahryar Eghtesadi completed his Bachelor Degree in Nutrition Science and Food Chemistry in 1975, at Shahid Beheshti University of Medical Sciences, Tehran; MSPH Degree in Nutrition in 1977 at Tehran University of Medical Sciences, Tehran and PhD in Nutrition in 1985 at University of California at Davis (UCD), USA. He served as Visiting Scientist in USDA Human Nutrition Research Center on Aging (HNRCA), Boston, USA (1994-1995); Full Professor of Tabriz, Iran and Tehran University of Medical Sciences and currently serves as Professor of Azad University, Science & Research Branch. He was the Chair of Departments of Nutrition and Biochemistry, Biochemistry & Clinical Nutrition, Public Health Nutrition and Nutrition at aforementioned universities. He served as an Associate Dean and Dean of School of Public Health & Nutrition and School of Public Health of Tabriz and Iran University of Medical Sciences respectively. He has published numerous peer reviewed articles in journals and also edited several books and finally served as Principal Investigator of World Bank Project for Capacity Building in Nutrition in Iran.