Journal of Biotechnology & Biomaterials
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The objective of study was to evaluate the effect of n-butanol fraction (NBF) and ethyl acetate fraction (EAF) of flowers of
Butea monosperma (BM) against doxorubicin (DOX) induced nephrotic syndrome (NS). A single injection of DOX (7
mg/kg, i.v) induced severe nephrotic syndrome after 4 weeks of its administration and was associated with hypoalbuminemia,
hypoproteinemia, elevated serum urea (BUN), creatinine, hyperlipidemia, and a high urinary excretion of protein. Female
Sprague-Dawley rats were divided into 7 groups (n = 6). Group I was treated with vehicle. Group II to VII were injected with a
single dose of DOX (7 mg/kg, i.v.) to induce nephrotic syndrome. After administration of DOX, group I and II were treated with
(vehicle, p.o), Group III was treated with prednisolone (3 mg/kg, p.o.), while the test groups IV, V were administered NBF (100
and 200 mg/kg, p.o.) and test groups VI and VII were administered EAF (100 and 200 mg/kg, p.o.) respectively, daily for 28 days.
NBF (200 mg/kg, p.o.) reduced increase in urine protein excretion, plasma total cholesterol and triglycerides, BUN, creatinine.
NBF was found to be more potent than EAF. The results confirmed the involvement of free radicals in the pathogenesis of
nephropathy induced by DOX. The data suggest the potential of extract of Butea monosperma as a protective agent for nephrotic
syndrome as alternative or as an adjunct to conventional therapy. The antinephritic potential of Butea monosperma could be
attributed to its flavonoid and steroid content.
Nitish Chaudhari is currently persuing masters in pharmacy (Pharmacology) at Bombay College of Pharmacy, University of Mumbai, under the
guidance of Dr. M. N. Saraf, Principal and Professor of Pharmacology.
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