The Influence Of IL-10 Gene Polymorphisms On The Susceptibility To Hepatitis B Virus Infection: A Metaanalysis | 51363
Journal of Infectious Diseases & Therapy
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Interleukin 10 (IL-10) is a cytokine with anti-inflammatory functions. The results of different studies vary in the roles of the IL-10
SNPs in the susceptibility to the hepatitis B virus infection. In particular, the -1082 A/G, -819 C/T and -592 A/C polymorphisms
have most often been implicated. We have performed a meta-analysis including 31 case-control studies to summarize the data on the
association between IL-10 SNPs and susceptibility to HBV infection. All the relevant studies in NCBI PubMed, EMBASE, Medline
and Web of Science were searched and poor qualified studies were excluded. 31 studies were included. Data are presented as the
odds ratio (OR) with a 95% confidence interval (CI). Investigation of heterogeneity among individual studies and the publication
bias were also evaluated. This study revealed a significant association between the IL-10-89 C/T polymorphism and HBV infection
susceptibility in the Asian population. Our results indicated that the presence of the IL-10 -819 C allele significantly increased the
risk for persistent HBV infection. In our meta-analysis, sensitivity analysis showed that the combined result was not associated with
the worldwide population. In contrast, the IL-10 -1082 A/G and -592 A/C polymorphisms were not associated with an increased
susceptibility to HBV infection. Our meta-analysis supports the growing body of evidence that the presence of the IL-10-819 C/T
SNP is associated with persistent HBV infection in Asians. In addition, IL-10-819 C/T polymorphism might be a risk factor for HBV
in Asians but not in Europeans.