alexa The Role Of Endothelial Biomarkers In Breast Cancer Metastasis
ISSN: 2476-2067

Toxicology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th World Congress on Toxicology and Pharmacology
April 13-15, 2017 Dubai, UAE

Maria Walczak
Jagiellonian University, Poland
ScientificTracks Abstracts: Toxicol Open Access
DOI: 10.4172/2476-2067.C1.002
Abstract
Statement of the Problem: Metastatic cancers are the main cause of cancer-related death in the world. For this reason identification of novel treatment targets is warranted. Study of breast cancer metastasis is limited due to poor knowledge in progression of breast tumor and varied heterogeneity. Breast cancer metastasis is a complicated process in which each step is modulated by a complex network of signaling pathways. In recent years attention is paid to the significance of vascular endothelium in cancer metastasis and abundant evidence suggests that endothelial inflammation plays an important pathogenetic role in the development of metastasis. The purpose of this study was to describe changes in endothelium in mouse model of 4T1 metastatic breast cancer at various stages of disease progression with the use of the multi-protein panel of endothelial biomarkers. Methodology & Theoretical Orientation: The panel contains proteins of glycocalyx disruption: syndecan-1 (SDC-1) and endocan (ESM-1); pro-inflammatory molecules: soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1) and soluble form of E-selectin (sE-sel); pro-thrombotic molecule: von Willebrand factor (vWF); fibrinolytic molecules: plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (t-PA); pro-angiogenic molecules: the soluble form of the fms-like tyrosine kinase 1 (sFlt-1), angiopoietin 2 (Angpt-2) and adrenomedullin (ADM), and protein secreted by adipocytes - adiponectin (ADN). The biomarkers were determined using the liquid chromatography/ mass spectrometry-multiple reaction monitoring-based method (LC/MS-MRM). Findings: Some of these proteins altered during breast cancer progression. Using a panel of selected molecules was enabled to identify endothelial biomarkers for early and late metastatic phase. Conclusion & Significance: Endothelial dysfunction in cancer confirms the hypothesis that condition of endothelium is a key step for disease development. The simultaneous analysis of many biomarkers in one sample enables for multidimensional screening of endothelial function in mouse 4T1 breast cancer.
Biography

Maria Walczak has graduated from the Faculty of Pharmacy, Medical Academy in Krakow. She has obtained her PhD degree from the Faculty of Pharmacy, Jagiellonian University Medical College (UJ CM), Krakow in 2001 and habilitation thesis in Pharmacokinetics in 2014. Since 2001, she worked at the Department of Pharmacokinetics and Physical Pharmacy UJ CM as a Lecturer, since 2010 at the Jagiellonian Centre for Experimental Therapeutics (JCET) as a Manager of the Laboratory of Analytics and Pharmacokinetics, and since 2015 as a Head of Chair at Department of Toxicology, Faculty of Pharmacy UJ CM. Her scientific work refers to pharmacokinetic and toxicokinetic profiling, metabolite screening, assessment of protein binding of bioactive compounds and pharmacology of endothelium. She is keen in bioanalysis of novel compounds and biomarkers related to cancer metastasis using LC/MS/MS and CE techniques. She is a specialist in clinical pharmacy issues.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords