Journal of Infectious Diseases & Therapy
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Background: The main objective in post-osteosynthesis surgical site infection (SSI) is to consolidate the fracture and prevent chronic
osteomyelitis, the risk factors for SSI relapse in these patients, who were treated as per osteo-articular infection protocol were evaluated
at the Federal University of São Paulo.
Methods: After retrospectively evaluating all SSI episodes occurring from December, 2004 to 2008 in patients undergoing
osteosynthesis at the orthopedics department, 110 of them were included. SSIs were treated with at least 4-6 week antibiotic therapy
cycles and followed up for one year with the results being analyzed using univariate and multivariate analysis models.
Results: Most patients were 18-89 year old (mean, 39.8 years) males (84.5%). In 37 patients, the causative agent was isolated
with Staphylococcus being the most frequently observed (38.8%). In 83 (75.4%) patients, the antimicrobial treatment mostly with
ciprofloxacin and clindamycin could be started within less than five days from the onset of symptoms. SSI relapses occurred in
34/110 (30.9%) patients. After one-year follow-up, 19 (17.3%) patients persisted with infection and only 10 (9.1%) did not have
their fractures consolidated. The univariate analysis showed the performance of more than one surgery to stabilize the affected limb
(OR 3.7 IC95=1.1-12.7 p=0.045), presence of converting osteosynthesis (OR 3.6 IC95=1.1-11.3 p=0.023), internal synthesis (OR 3.0
IC95=0.99-9.2 p=0.043) and longer duration of surgery (OR 0.4 IC95=0.1-1.6 p=0.029) as risk factors for SSI relapse. In the multivariate
analysis, the only variable independently associated with SSI relapse was duration of surgery (OR 1.3 IC95=1.1-1.7 p=0.015).
Conclusions: After one-year follow-up, using a specific protocol, most patients showed resolution of infection and only 9.1% had
their fractures unconsolidated. The only independent risk factor associated with SSI relapse was prolonged surgery.
Adriana Macedo Dell’Aquila has completed her PhD from Federal University of São Paulo, Brazil. She is the infectious disease Physician responsible for the control and treatment of osteoarticular infections, Department of Orthopedics and the control of infections in the Burns Unit of São Paulo Hospital, Federal University of São Paulo.