Journal of Biotechnology & Biomaterials
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To compare the therapeutic efficacy and safety of fexofenadine with chlorpheniramine maleate in the treatment of allergic rhinitis and bethmethasone, short course therapy given orally in allergic rhinitis
INTRODUCTION:Allergies are among the most common diseases affecting millions of people throughout the world.
A significant percentage of Indian population affects from one or the other allergic disorders. Allergic rhinitis is one of the
commonest allergic disorders. It is sensitization of the nasal mucosa by the allergens leads to the allergic response in the nasal
cavity resulting in the typical symptoms of sneezing, watery nasal discharge, itching and blocking of nose. These symptoms cause
considerable disturbance to the normal daily activities and even be a forerunner for more severe forms of allergy like Bronchial
The present treatment options for Allergic Rhinitis include: Oral Antihistamines, Topical Corticosteroids, Oral Corticosteroids
(Short Course), Topical Anticholinergics and Immunotherapy (Desensitization) of all these Anti Histamines are the most
OBJECTIVE: 1] Comparing the therapeutic efficacy and safety of second generation anti histamine eg:fexofenadine with first
generation eg:chlorpheniramine maleate. 2] Comparing the therapeutic efficacy and safety of Anti histamines with other group
of drug used in allergic rhinitis ( i.e)Bethamethasone orally short course.
INCLUSION CRITERIA: patients between age 15-45. Number of cases 75.
METHODS: ENT examination.complete Blood Picture,Absolute eosinophil count, X Ray of paranasal sinuses,skin test for
Allergy, IgE levels in the serum.
CONCLUSION: The three drugs fexofenadine, chlorpheniramine maleate and Bethamethasone were and found to have similar
levels of efficacy in controlling the symptoms of allergic rhinitis. The physical signs improved better with chlorpheniramine
than other two drugs. Fexofenadine was found to be most effective in suppression of the skin reaction to the allergens. It was
closely followed by Betamethasone and then chlorpheniramine. The anti-histamines Fexofenadine and Chlorpheniramine had
no significant effect on the absolute eosinophil count and serum ?IgE levels. Whereas Betamethasone had significant effects.
Adverse effects were reported more by patients on chlorpheniramine maleate than with Fexofenadine or Bethamethasone.
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