Journal of Biotechnology & Biomaterials
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Umbilicus rupestris(UR) is an herbal medicine traditionally applied medicine against the ignitions of the skin. The present
study was aimed to study the acute and subacute toxicity studies with orally administered methanolic leaves extract of
mbilicus rupestris L
(URMeOH). In acute toxicity tests, four groups of rats (n=6/group/female) were orally treated with
doses of 500, 1000, 1500 and 2000 mg/kg, and general behavior, adverse effects, and mortality were recorded for up to 14 days.
In subacute toxicity study, rats received URAMeOH by gavage at the doses of 100, 200 mg/kg/day (n=6/group) for 28 days,
and biochemical, hematological, and histopathological changes in tissues (liver, kidney) were determined. URMeOH did not
produce any hazardous symptoms or death and in the acute toxicity test. Subacute treatment with URMeOH did not show any
change in body weight, and hematological and biochemical profiles. In addition, no change was observed both in macroscopic
and microscopic aspects of vital organs in rats. Our result showed that Umbilicus rupestris extract could be safe for human use
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