alexa Two Stage, Dual Action Cancer Therapy With Targeted Porous Silicon Nanoparticles
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

2nd Annual Conference and Expo on BIOMATERIALS
March 27-28, 2017 Madrid, Spain

Anna Cifuentes-Rius, Angela Ivask and Nicolas H Voelcker
Monash University, Parkville campus, Australia
National Institute of Chemical Physics and Biophysics, Estonia
ScientificTracks Abstracts: J Biotechnol Biomater
DOI: 10.4172/2155-952X.C1.073
Despite the advances in developing efficient chemotherapy drugs, their efficacy may be diminished by the predisposition of some tumors to drug resistance and non-specific toxicity. Nanomedicine offers the possibility of tackling these key clinical challenges, by designing target delivery platforms for a combination of cancer therapies. To overcome drug resistance, we explore the synergy of hyperthermia with conventional chemotherapy. Due to the higher susceptibility of cancer cells to elevated temperatures compared to healthy cells, hyperthermia stimulates the uptake of anticancer drugs in tumor cells. Thus, nanoparticle (NP)-based delivery systems combining hyperthermia with traditional chemotherapeutics may afford the efficient treatment of highly drug-resistant tumors. Additionally, NP vectorization of therapeutics by actively targeting membrane receptors overexpressed in cancer cells has been recently suggested as a way to ensure selective delivery and improve therapeutic outcomes. Porous silicon (pSi) NPs are (i) biodegradable, (ii) suitable for conjugation with moieties for targeting of a specific cell population, and (iii) exhibit efficient loading of chemotherapy drugs. Here, we utilized these unique characteristics of pSiNPs and loaded them with multiple therapeutics while also immobilizing cell-specific antibodies to achieve active targeting. We have developed antibody functionalized pSi NP loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs). By selective targeting, these nanocarriers were observed to actively deliver both the chemotherapy drug and AuNCs to human B cells. The accumulation of AuNCs to target cells rendered them more susceptible to the co-delivered chemotherapy drug when an external electromagnetic field in the microwave region was applied. This approach represents a targeted two-stage delivery nanovector that takes advantage of dual therapeutic action in order to enhance cytotoxicity.

Anna Cifuentes-Rius is an NHMRC Early Career Fellow at the Future Industries Institute and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. She is working in the design of three-dimensional nanoarchitectures of bioresponsive nanoparticles, containing drugs and bioactives for a range of therapeutic targets including cancer. Her interdisciplinary research is largely focused on the understanding of the biointerface of advanced bio and nano-materials for the application in the emerging field of theranostics.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicals[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version