alexa Virtosomes ? Intracellular Messengers?
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

5th World Congress on Biotechnology
June 25-27, 2014 Valencia Conference Centre, Valencia, Spain

Mariapia Viola-Magni, Samuela Cataldi, Maurice Stroun and Peter B.Gahan
ScientificTracks Abstracts: J Biotechnol Biomater
DOI: 10.4172/2155-952X.S1.027
Abstract
Virtosomes are cytosolic complexes formed from newly synthesized DNA, RNA, protein and lipid and have been demonstrated to be present in human and other mammalian, avian, amphibian and tumour cells. The phospholipid composition is different to that of the cell membrane being rich in sphingomyelin (SM) and phosphatidylinositol (PHI), but with lower phosphatidylcholine levels. Previous experiments have shown SM to stabilize chromatin, especially protecting RNA, whilst PHI is important for transport across membranes. Stimulated lymphocyte (SL) virtosomes differ from those from non-stimulated lymphocyte (NSL) in both molecular weight and protein content. They are released from cells and have been demonstrated to enter other cells and their nuclei. Based upon studies of in vivo immune responses and in vitro studies on the switch on-and-off of DNA synthesis in non-dividing and dividing cell lines and tumour cell lines, it was proposed that virtosomes act as intra-cellular messengers. It also implies that synthesis of new proteins occurs in the recipient cells. Our recent studies showing that virtosomes from SL populations initiate cell replication in NSL populations and those from NSL inhibit SL confirm this hypothesis. This could happen also during hepatocyte maturation in newborn rats when the synthesis of specific proteins reaches a high level in the absence of cell duplication, being due to the loss of and new synthesis of DNA so transforming a large number of cells. Metastasis may occur other than through cell migration, possibly through tumour cell virtosomes being transferred to other cells.
Biography
Degree in Medicine and Surgery, PhD Scuola Normale Superiore, professor of General Pathology at the Faculty of Medicine of Perugia University from 1975. Delegate of International affairs, President of TUCEP Consortium and actually of ONLUS Foundation for research ?Enrico Puccinelli?. Authors of more than 300 publication most on International Journal. Scientific fields of interest are:cell proliferation in vivo and in vitro ;non premitotic DNA synthesis; tumor cell proliferation and oncogene expression; gene expression in hepatocytes during neonatal maturation and liver regeneration; presence of a phospholipidic fraction in hepatocyte chromatin and its metabolism presence of DNA in blood and in biological fluids.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifooda[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords