Sung K Cho | OMICS International
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Sung K Cho

Armed Forces Medical Research Institute, 90 bun, Jaunro, Yuseong-gu, Daejeon 305-878

The Synergistic Effects of Pioglitazone on the Glucose-Lowering Action of Metformin in Relation to OCT1 and Gluts m-RNA Expression in Healthy Volunteer

Objective: Organic Cation Transporter 1 (OCT1) plays a key role in the disposition of metformin in hepatocytes; a recent non-clinical study reported that the peroxisome-proliferator activated receptor γ agonist pioglitazone increased the expression of Slc22a1 (Oct1) by 3.1-fold as well as its transporting function. We therefore evaluated the ... Read More»

Sung K Cho

Research Article: Clin Pharmacol Biopharm 2015, 4:129

DOI: 10.4172/2167-065X.1000129

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF