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Effects of Simulated Weightlessness on Metabolizing Enzymes and Zolpidem Pharmacokinetics in SD Rats
Zolpidem is a known hypnotic for astronauts in spaceflight. Up until now, the effect of microgravity on the pharmacokinetics of zolpidem remained unclear. The pharmacokinetics of zolpidem in SD rats were studied under both short-term and long-term simulated weightlessness, laying the foundation for safe administration to astronauts. The plasma conc... Read More»
Xueying Liu, Yang Zhang, Juan Jing, Jialong Liang, Jun Zhao, Ruitao Zhang, Xuejiao Zhou, Jianyi Gao, Jiaping Wang, Yongzhi Li and Qingwei Wang
: Clin Pharmacol Biopharm
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