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Ankur Sharma obtained his B. Pharm from University of Rajasthan, Jaipur, India and his MS in Pharmacology from Rajiv Gandhi Technical University, Bhopal, India. After his MS he worked as a Research Associate in pre-clinical pharmacology R&D department of Piramal Life Sciences in India. Ankur Sharma has received his Ph.D. in Pharmaceutical Sciences from The University of Oklahoma, Health Sciences Center, College of Pharmacy. He was an ORISE fellow in the Office of Generic Drugs of US FDA in Department of Quantitative Methods & Modeling. Currently he is serving as a Senior Scientist in Quantitative Pharmacology & Pharmacometrics Department of Merck. His most significant research contributions include utilizing quantitative approaches like physiologically based pharmacokinetic modeling, and PK/PD modeling for quantitative prediction of drug levels in tumors with a possibility of human scale-up to enable First-in-Human (FIH) dose selection in cancer patients, determining mechanistic strategies to overcome tumor-resistance in ovarian cancer, bioanalytical method development for analysis of anti-cancer drugs in human plasma, utilizing PBPK approaches for ocular drug translation from animal data to predict human ocular PK and PD, and developing prodrugs for NSAIDs for improved efficacy and safety.
Bioanalytical Method Development, PBPK Modeling, PK/PD modeling, Population Based PK Modeling, Cancer cell biology, Immunology.