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Brucellosis and systemic lupus erythematosus are two diseases with different origin and treatment targets characterized by multi-organ involvement particularly affecting central and peripheral nervous systems. It is known, that clinical symptoms of brucellosis are non-specific and can mimic many other diseases. Previously, it has been reported that slightly positive serological tests in some diseases (such as lymphoma, typhoid fever and malaria) have led to misdiagnosis of brucellosis. In our paper we report a case of systemic lupus erythematosus with bilateral “drop foot” misdiagnosed as brucellosis which recovered after appropriate treatment aimed at lupus.