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A neuro-toxoplasmosis was diagnosed in an HIV infected child stage AIDS C3. Case report: The patient coursed with recurrent respiratory infections, persistent cough with shortness of breath, fatigue, weakness, oral white plaques and fever predominantly at night up to 40°C. Mycobacterium tuberculosis was discarded. Then the patient had neurological impairment and Computerized Tomography (CT) scan of brain showed hyper dense images in the left sylvian aqueduct and in the right lenticular nucleus, the latter one with mixed concentric densities. Reactivation of toxoplasmosis was documented by high titers of IgG antibodies by Enzyme Linked Immunoabsorbent Assay (ELISA) corroborated by Western-blot.