alexa Orotic Acid: Why it is Important to Understand Its Role in Metabolism. | Open Access Journals
ISSN: 2168-9652
Biochemistry & Physiology: Open Access
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Orotic Acid: Why it is Important to Understand Its Role in Metabolism.

Thomas P West*, Chunduru J and Eswara C Murahari

Department of Chemistry, Texas A&M University-Commerce, Commerce, USA

*Corresponding Author:
Thomas P West
Department of Chemistry
Texas A&M University-Commerce
Commerce, TX 75429-3011, USA
Tel: +1-903-886-5381
Fax: 903-468-6020
E-mail: [email protected]

Received date: April 22, 2017; Accepted date: April 24, 2017; Published date: April 29, 2017

Citation: West TP, Chunduru J, Murahari EC (2017) Orotic Acid: Why it is Important to Understand Its Role in Metabolism? Biochem Physiol 6:e157. doi:10.4172/2168-9652.1000e157

Copyright: © 2017 West TP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Biochemistry & Physiology: Open Access

The molecule orotic acid was originally thought to be a vitamin that was essential to animal nutrition. Vitamin B13 was originally postulated to be present in distillers dried soluble from grains. It was later determined that vitamin B13 or orotic acid was synthesized by mammals during the synthesis of pyrimidines using the de novo pyrimidine biosynthetic pathway [1,2]. In humans and other organisms, orotic acid is synthesized by the enzyme dihydroorotate dehydrogenase which converts dihydroorotate to orotic acid [3]. It has been found that orotic acid improves the metabolism of folic acid and vitamin B12. Orotic acid is found in milk produced by cows and other commercial dairy products derived from milk. The presence of orotate in mammals is important to the development of the central nervous system [1]. The importance of orotic acid in human metabolism can be witnessed in individuals afflicted with orotic aciduria. Orotic aciduria is detected in humans by virtue of affected individuals excreting excess orotic acid. This autosomal recessive disorder has been associated with developmental retardation.

Two forms of orotic aciduria have been distinguished in humans. Type I form of orotic aciduria is caused by the loss of uridine 5’-monophosphate synthase activity. The other form of orotic aciduria is associated with megaloblastic anemia [4-6]. Megaloblastic anemia results due to DNA synthesis inhibition in human red blood cells. Recently, it was noted that the administration of orotic acid in humans improved the condition of hearts with hypertrophy. It was concluded that the positive effect of administering orotic acid to humans with hypertrophic hearts was caused by the release of pyrimidine nucleosides into the blood stream blocking adenine nucleotide depletion in the myocardium [7]. It has also been observed that salts of orotic acid, including zinc or magnesium orotate, can be used in metal ion substitution therapy [5]. Negative effects have also been observed with respect to orotic acid since insulin resistance and hypertension or fatty livers can be induced in rats when orotic acid is included in their diet [8,9]. The hypertension observed in orotic acid-fed rats was thought to be the result of impaired endothelial nitric acid synthesis [8]. With respect to gene transcription, it has been speculated that orotic acid may influence the synthesis of genes involved in cell proliferation in eukaryotes [1]. In prokaryotes, the supplementation of orotic acid to Pseudomonas fluorescens, Pseudomonas putida and Pseudomonas lundensis cells was shown to increase the transcription of the pyrimidine biosynthetic pathway enzyme dihydroorotase, orotate phosphoribosyltransferase or orotidine 5’-monophosphate decarboxylase [10-12].

It is clear that orotic acid can affect gene transcription in both prokaryotes and eukaryotes. In summary, the importance of orotic acid, previously identified as vitamin B13, in metabolism has been known since its discovery in 1905 [1] but recent research findings have demonstrated that orotic acid likely has additional roles in metabolism. Only recently has a more intensive effort been made to learn the relationship between orotic acid levels and its cumulative effect upon metabolism. Further analysis of the role that this pyrimidine base occupies in metabolism needs to be elucidated to more fully understand its overall importance.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • 2nd International Conference on Biochemistry
    September 28-29, 2017 Dubai, UAE
  • 3rd Annual Congress on Bioscience
    October 16-17, 2017 Dubai,UAE
  • 3rd International Conference on Transcriptomics
    October 30 - November 01, 2017 Bangkok, Thailand
  • 3rd International Conference on Genetic and Protein Engineering (10 Plenary Forums - 1 Event)
    November 08-09, 2017 Las Vegas, USA

Article Usage

  • Total views: 315
  • [From(publication date):
    June-2017 - Sep 25, 2017]
  • Breakdown by view type
  • HTML page views : 275
  • PDF downloads :40
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords