Analyzing the Correlation of Serum Iron Parameters with Paraoxanase, Arylesterase and Oxidative Stress Markers in Stem Cell Transplantation Patients
|Hasan Karageçili1*, Hatice Pasaoglu2, Gülsan Türköz Sucak3 and Elif Suyani4|
|1Siirt University, School of Health, Siirt, Turkey|
|2Gazi University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey|
|3Gazi University, Faculty of Medicine, Department of Hematology, Ankara, Turkey|
|4Istanbul Education and Searching Hospital, Department of Hematology, Ä°stanbul, Turkey|
|Corresponding Author :||Hasan Karageçili
Siirt University, Health School
Street Gures 56100
Tel: 00 90 (484) 223 1056, Gsm: 505 586 3397
Fax: 00 90 (484) 223 5156
E-mail: [email protected], [email protected]
|Received: April 30, 2015; Accepted: July 08, 2015; Published: July 15, 2015|
|Citation: Karageçili H, Pasaoglu H, Sucak GT, Suyani E (2015) Analyzing the Correlation of Serum Iron Parameters with Paraoxanase, Arylesterase and Oxidative Stress Markers in Stem Cell Transplantation Patients. Biochem Physiol 4:169. doi: 10.4172/2168-9652.1000169|
|Copyright: © 2015 Karageçili H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Background: Hematopoietic Stem Cell Transplantation (HSCT) itself is associated with morbidity and mortality, and impaired iron metabolism might have an impact on these complications. Iron, ferritin overload in tissues and systemic circulation, is importantly thought that (to) increase the oxidative stress.
Methods: In patients and controls serum iron, iron binding capacity and ferritin levels were measured. Antioxidant enzymes, Catalase (CAT), Glutathione peroxidase (GPx), Paraoxonase (PON), Arylesterase (ARE), and Glutathione-s Transferase (GST) activities were measured in the serum. These parameters and enzymes in relevance to malondialdehyde (MDA) were evaluated.
Results: Serum MDA levels were significantly increased in the autologous group compared with the control group (p < 0.05). Serum glutathione peroxidase and CAT activity levels were lower in allogeneic and autologous groups, a significant difference was not observed between groups (p > 0.05). Serum PON activity levels in autologous were found to be low when compared with the control group (p < 0.05). In terms of serum iron levels, statistically significant difference were found between allogeneic, autologous and the control group (p < 0.05). Serum ferritin levels were found high in allogeneic and autologous groups than the control group (p < 0.05). According to Spearman’s correlation analysis, between serum MDA level and GPx activity in serum, a negative correlation was found. Between serum MDA and serum GST, and between serum PON activity and serum ARE activity were found a positive correlation.
Conlusions: Serum and tissues ferritin overload and the decrease in antioxidative enzymes activity levels may be harmful to body, causing some types of blood cancer diseases.