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Hindi Cell Migration: Mechanics, Regulation, and Disease
*Corresponding Author: Dr. Emily T. Robinson, Sydney Biochemistry & Molecular Biology Institute, Australia, Email: e.robinson@sydneybio.au
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Abstract
Cell migration is a fundamental process in health and disease, encompassing embryonic development, immune function, and cancer metastasis. Cells navigate environments by adjusting internal forces like actomyosin contractility and focal adhesions in response to matrix stiffness. The cytoskeleton and adhesion dynamics are crucial for immune cell movement, regulated by Rho GTPases. Collective cell migration offers potential in tissue engineering and regenerative medicine. Mechanotransduction and microenvironmental cues guide cellular responses, playing pivotal roles in physiological processes and disease pathogenesis. Therapeutic strategies target cell migration in cancer, with nanotechnology showing promise against metastasis, often involving epithelial-mesenchymal transition. Understanding these mechanisms is vital for novel therapeutic interventions
