Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Dose-Dependent Effects of Paraquat on C-reactive protein, Some Lipid Profile Parameters and Histology of Tissues in Male Albino Rats | OMICS International | Abstract

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Dose-Dependent Effects of Paraquat on C-reactive protein, Some Lipid Profile Parameters and Histology of Tissues in Male Albino Rats

Akinloye OA*, Abioye OA, Olaojoyetan OE, Awosika OT and Akinloye DI
Department of Biochemistry, Federal University of Agriculture, P.M.B 2240, Abeokuta, Nigeria
*Corresponding Author : Dr. Akinloye OA
Department of Biochemistry
Federal University of Agriculture
P.M.B 2240, Abeokuta, Nigeria
Tel: +2348030824063
Received January 02, 2013; Accepted January 28, 2013; Published January 31, 2013
Citation: Akinloye OA, Abioye OA, Olaojoyetan OE, Awosika OT, Akinloye DI (2013) Dose-Dependent Effects of Paraquat on C-reactive protein, Some Lipid Profile Parameters and Histology of Tissues in Male Albino Rats. Biochem Physiol 2:106. doi:10.4172/2168-9652.1000106
Copyright: © 2013 Akinloye OA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Paraquat is a highly toxic and widely used herbicide with no antidote. Its toxicity in man and animals has been reported to cause severe acute and long term health problems which eventually could lead to death. Measurement of blood C-Reactive Protein level (CRP) serves as a useful screen for infections and inflammatory diseases. Since it is known that paraquat exerts its toxic effects through generation of reactive oxygen species which causes injury to the cells thereby causing inflammation, this study was designed to determine the dose-dependent effects of paraquat on C-reactive protein, cholesterol, triglycerides and histology of liver and kidney in rats. Thirty albino rats weighing between 150 g and 200 g grouped into five groups of six rats in each were used. Rats in group A serves as control and were given feed and water only freely. Rats in group B, C, D and E were treated orally with 15 mg/kg (below sublethal dose), 25 mg/kg (sub-lethal dose), 35 mg/kg (below lethal dose) and 45 mg/kg (below lethal dose) of paraquat dichloride respectively for a period of fourteen days. The blood plasma collected was analyzed for CRP (using an immune-turbidimetric assay method), cholesterol and triglycerides while liver and kidney excised from sacrificed rats were used for histopathological studies. The result obtained showed that the concentration of CRP (12.38 ± 0.09 mg/L), cholesterol (8.61 ± 0.49 mg/L) and triglycerides (189.47 ± 2.59 mg/L) in control group was significantly lower (p<0.05) than the other groups. The higher the concentration of paraquat administered, the higher its toxicity and the higher the levels of CRP, cholesterol and triglycerides. Histopathological findings revealed some pathologic conditions ranging from diffuse vacuolar degeneration of hepatocyte and glomerular mesangiolysis in the liver and kidney of paraquattreated group respectively. This present study therefore suggests that the induction of inflammation and oxidative damage by paraquat could be accompanied by elevated C-reactive protein, cholesterol and triglycerides in albino rats.