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ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Research Article

Fast Side-Chain Dynamics: Measurement, Analysis, and Their Role in Protein Function

Chad M Petit*
Department of Biochemistry and Molecular Genetics, University of Alabama, USA
*Corresponding Author : Chad M Petit
Department of Biochemistry and Molecular Genetics
University of Alabama, 720, 20thStreet South
Kaul Human Genetics, Room 452, Birmingham, AL 35294, USA
E-mail: [email protected]
Received February 06, 2013; Accepted May 13, 2013; Published May 16, 2013
Citation: Petit CM (2013) Fast Side-Chain Dynamics: Measurement, Analysis, and Their Role in Protein Function. Biochem Physiol S2:006. doi:10.4172/2168-9652.S2-006
Copyright: © 2013 Petit CM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Proteins are dynamic molecules that use coordinated atomic fluctuations to achieve proper function. These motions have fundamental implications for not only understanding how proteins function, but current methods of structure based drug design. In this review, we focus on providing an overview of the NMR experiments to detect side-chain motions and their applications, to characterize to conformational entropy, allostery, and proper protein function.

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