Modification of Carbon Nanotubes with Electronegativity Molecules to Control the Adhesion of Low Density Lipoprotein
- *Corresponding Author:
- Juan Esteban Berrio Sierra
Centro de Investigación en Materiales Avanzados, CIMAV. Alianza Norte 202
Parque de Investigación e Innovación Tecnológica. Apodaca, Nuevo León, México CP 66600
E-mail: [email protected]
Received date: March 28, 2016; Accepted date: April 27, 2016; Published date: May 05, 2016
Citation: Sierra JEB, Cornelio JAC, García AG, Osorno JB, Palacio LMH (2016) Modification of Carbon Nanotubes with Electronegativity Molecules to Control the Adhesion of Low Density Lipoprotein. Biochem Physiol 5:203. doi:10.4172/2168-9652.1000203
Copyright: © 2016 Sierra JEB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Atherosclerosis is a cardiovascular disease that causes accumulation of lipoproteins, which leads to vascular injury and may even cause Acute Myocardial Infarction (AMI). The interaction of vascular endothelium with low - density lipoproteins (LDL) was modified by using two distinct groups of carbon nanotubes (CNTs). The first group was doped with aluminum sulfate (Al2(SO4)3) and boric acid (H3BO3), and the second group was functionalized by chemical route with carboxylic acid (COOH) and glucosamine (C6H13NO5). The catalysts used to grow the CNTs were Nickel (Ni) 50%, Cobalt (Co) 50% and Cobalt Iron (Fe - Co) 10% - 40%, by sol - gel route. Scanning electron microscopy (SEM), Raman, and contact angle were used to characterize CNTs. The Raman spectra of multi - wall carbon nanotubes showed three bands, which are called D (disorder), G (graphitization) and G’ (second harmonic order) which caused by the D band. It is observed that the intensity ratio ID / IG increases for functionalized CNTs. CNTs grown from nickel and functionalized by chemical route with glucosamine showed low wettability contact angle for the 2h and 18h oxidized LDL samples. CNTs grown from nickel and doped with aluminum sulfate showed an angle of contact with low wettability for the 2h oxidized LDL sample. An association of the sulphate groups in the density of the load and the cooperativity of the load with arginine and lysine rich peptides of the LDL sample were observed. The CNT catalyzed with (Fe - Co) and doped with boric acid evidenced a low strength of adhesion and greater surface tension for the 18h high degree oxidized LDL; resulting in a repulsion of residues of lysine and arginine of the altered structure of ApoB 100 of the LDL. The obtained CNT structures are presented as a possible devise coating with therapeutic potencial to avoid the progression of atherosclerosis.