Potential Drug Targets in the Death Pathway: Therapeutic Approaches in Apoptosis | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Potential Drug Targets in the Death Pathway: Therapeutic Approaches in Apoptosis

Md. Salahuddin1*, Md. Shariful Islam2, Abu Zaffar Shibly2, Hasibul Haque Rakib2, Muhammad Jahangir Hossen3, Md. Ramim Tanver Rahman4, MA Momin5, Md. Sayfullah Razin6, Jay Prakash Sah7, Md. Abdur Rahman8, Muhammad Aurang Zeb9 and Mizanur Rahman Washim10
1Faculty of Medicine, University of Hongkong, Pokfulam Road, Hongkong
2Department of Biotechnology and Genetic Engineering, Faculty of Life science, Mawlana Bhashani Science and Technology University, Tangail-1902, Bangladesh
3Department of Animal Science, Patuakhali Science and Technology University, Bangladesh
4National Engineering research Centre for functional Food, Jiangnan University, Wuxi 214122, PR China
5Department of Microbiology, Faculty of Veterinary Medicine, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh
6College of Medicine, Shaheed Ziaur Rahman Medical College, Bogra, University of Rajshahi, Bangladesh
7Department of Medical Laboratory Science, School of Health and Allied Sciences, Pokhara University, Lekhnath -12 Kaski, Nepal
8Faculty of veterinary Medicine, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh
9Department of Biochemistry, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan
10Bangladesh Fisheries research Institute, Mymensing, Bangladesh
Corresponding Author : Md. Salahuddin
PhD Research Fellow
Faculty of Medicine, University of Hongkong
Pokfulam Road, Hongkong
Tel: +852-5584- 1096
E-mail: [email protected]om
Received: October 26, 2015; Accepted: October 27, 2015; Published: November 03, 2015
Citation: Salahuddin M, Shariful Islam M, Shibly AZ, Rakib HH, Hossen MJ, et al. (2015) Potential Drug Targets in the Death Pathway: Therapeutic Approaches in Apoptosis. Biochem Physiol 4:e141. doi:10.4172/2168-9652.1000e141
Copyright: © 2015 Salahuddin M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The form of programmed cell death known as Apoptosis has become an intense focus of investigation in various fields including carcinogenesis and cancer therapy. It is a sequentially regulated suicidal programme where cells regulate certain enzymes including caspase 9 activation and cytochrome C release with apoptosis inducing factor (AIF). The Bcl-2 proteins also represent a promising target for modulating tumor cell sensitivity to Apoptosis. Disturbance of this regulatory pathway may lead to various diseases like autoimmune diseases, neurodegenerative diseases and cancers. Therefore, understanding the mechanisms for apoptosis signaling pathway will give us huge knowledge to enlighten the pathogenesis of various diseases including cancer, and will open new horizons to therapeutic approaches in drug designing.


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