Potential Role of TLR Ligand in Aethiopathogenesis of Tunisian Endemic Pemphigus Foliaceus | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Research Article

Potential Role of TLR Ligand in Aethiopathogenesis of Tunisian Endemic Pemphigus Foliaceus

Olfa Abida1*, Bouzid D1, Krichen-Makni S2, Kharrat N5, Masmoudi A3, Abdelmoula M4, Ben Ayed M1, Turki H3, Sellami-Boudawara T2 and Masmoudi H1
1Immunology Department, Habib Bourguiba Hospital, University of Sfax, Tunisia
2Anatomy and Pathology Department, Habib Bourguiba Hospital, Sfax, Tunisia
3Dermatology Department, Hédi Chaker Hospital, Sfax, Tunisia
4Maxillofacial Surgery Department, Habib Bourguiba Hospital, Sfax, Tunisia
5Bioinformatics’ Unit, Biotechnology Center of Sfax, Sfax, Tunisia
*Corresponding Author : Olfa Abida
Immunology Department
Habib Bourguiba Hospital
University of Sfax, PTT El Bustan
BP 10 A, 3099 Sfax, Tunisia
E-mail: [email protected]
Received September 17, 2013; Accepted October 16, 2013; Published October 21, 2013
Citation: Abida O, Bouzid D, Krichen-Makni S2, Kharrat N, Masmoudi A et al. (2013) Potential Role of TLR Ligand in Aethiopathogenesis of Tunisian Endemic Pemphigus Foliaceus. Biochem Physiol 2:117. doi:10.4172/2168-9652.1000117
Copyright: © 2013 Abida O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and source are credited.


Pemphigus foliaceus (PF) is an autoimmune skin disease in which environmental factors are thought to participate. Recent studies suggest that microbial components use signaling molecules of the human Toll-like receptor (TLR) family to transduce signals in keratinocytes. The aim of our research was to investigate the expression of TLRs 2, 3 and 4 by keratinocytes of PF patients compared to normal keratinocytes, in order to characterise the nature of the microbial factor involved in the etiopathology of PF. Biopsies obtained from 43 PF patients and 20 healthy controls were assessed by immunohistochemical analysis using specific polyclonal antibodies. The TLR2, TLR3 and TLR4 expression was significantly upregulated in PF epidermis. The significant increase of those TLRs simultaneously may merely reflect the complicated environmental conditions of rural women in the southern rural regions of Tunisia. Interestingly, we have found that the TLR4 diffuse expression was associated with the production of anti-desmoglein 1 Abs (p=0.037). This could be in line with a potential role of TLR ligand in aethiopathogenesis of Tunisian endemic PF. TLR over-expression in pemphigus skin indicates that TLRs are involved in the pathogenesis of pemphigus through stimulation by infectious or endogenous ligands.