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Prediction of Antigenic Peptide and MHC Binder from ITX-3 Tegenaria agrestis: Current Approach for Synthetic Vaccine Development | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Research Article

Prediction of Antigenic Peptide and MHC Binder from ITX-3 Tegenaria agrestis: Current Approach for Synthetic Vaccine Development

Sherkhane AS and Gomase VS*
The Global Open University, Nagaland, India
*Corresponding Author : Gomase VS
The Global Open University, Dimapur-797 112, Nagaland, India
Tel: 91-9987770696
E-mail: [email protected]
Received May 23, 2014; Accepted June 05, 2014; Published June 12, 2014
Citation: Sherkhane AS, Gomase VS (2014) Prediction of Antigenic Peptide and MHC Binder from ITX-3 Tegenaria agrestis: Current Approach for Synthetic Vaccine Development. Biochem Physiol 3:136. doi:10.4172/2168-9652.1000136
Copyright: © 2014 Gomase VS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Venom of Tegenaria agrestis species causes necrosis in humans. ITX-3 is a toxin with 68 amino acids. Antigenic peptides of Tegenaria agrestis toxic protein are most suitable for synthetic peptide vaccine development because with single epitope, the immune response can be generated in large population. In this research, we used PSSM and SVM algorithms for the prediction of MHC class I & II binding peptide, antigenicity, Solvent accessibility, polar and nonpolar residue to analyze the regions that are likely exposed on the surface of proteins which are potentially antigenic that allows potential drug targets to identify active sites as well as to design synthetic peptide vaccine.

Keywords

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Citations : 814

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