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ISSN: 2157-2526

Journal of Bioterrorism & Biodefense
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Research Article

Silver-N-Carboxymethyl Chitosan Nanocomposites: Synthesis and its Antibacterial Activities

Nguyen Tien An1*, Nguyen Thi Dong1, Pham Thi Bich Hanh1, Tran Thi Y Nhi1, Duong Anh Vu1, Do Thi Nguyet Que2 and Do Truong Thien1

1Institute of Chemistry – VAST, 18- Hoang Quoc Viet road – Hanoi –Vietnam

2Hanoi Pharmaceutical University, Hanoi, Vietnam

*Corresponding Author:
Nguyen Tien An
Natural Polymer Laboratory
Institute of Chemistry – VAST
18- Hoang Quoc Viet road, Hanoi, Vietnam
Email: [email protected]

Received Date: September 28, 2010; Accepted Date: November 12, 2010; Published Date: November 15, 2010

Citation: An NT, Dong NT, Hanh PTB, Nhi TTY, Vu DA, et al. (2010) Silver-N-Carboxymethyl Chitosan Nanocomposites: Synthesis and its Antibacterial Activities. J Bioterr Biodef 1:102. doi: 10.4172/2157-2526.1000102

Copyright: © 2010 An NT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In this work, silver-N-carboxymethyl chitosan nanocomposites (Ag-N-CMC) were synthesized in the homogeneous state via the reduction of Ag+ (using [Ag(NH3)2]OH instead of AgNO3) by NaBH4 in the presence of water-soluble N-carboxymethyl chitosan as a stabilizer. The resulting Ag-N-CMG was characterized by FTIR, TEM and UV-vis spectra. The results showed that the average particle size of silver nanoparticles was little affected by the concentration of Ag+ added and was between 2 and 10nm. The characteristic surface plasmon resonance band of silver nanoparticles centered at about 398 - 410nm. In vitro antibacterial activities of Ag-N-CMC nanocomposites were evaluated against both gram-negative bacteria: Escherichia coli ATCC 25922 (Ec) and Pseudomonas aeruginosa VM201 (Pseu) and gram-positive bacteria: Staphylococcus aureus ATCC 1128 (Sta) and Bacillus cereus ATCC 9946 (Bc). The results shown that the Ag-N-CMC nanocomposites could inhibit the growth and multiplication of the tested bacteria.

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