alexa Synthesis of Dihydroimidazole Derivatives under Solvent Free Condition and Their Antibacterial Evaluation | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Research Article

Synthesis of Dihydroimidazole Derivatives under Solvent Free Condition and Their Antibacterial Evaluation

Mahmoud Abd El Aleem Ali Ali El-Remaily1*, Shaaban K Mohamed2, Ahmed MM Soliman1, and Hossam Abd el-Ghanya1
1Department of Chemistry, Sohag University, Egypt
2School of Chemistry and Environmental Science, Manchester Metropolitan University, Manchester, England
*Corresponding Author : Abd El Aleem Ali Ali El-Remaily
Department of Chemistry
Sohag University, Sohag 82524, Egypt
Tel: +20108036348
Fax: +2093601159
E-mail: [email protected]
Received July 03, 2014; Accepted July 25, 2014; Published August 01, 2014
Citation: Ali El-Remaily MAEAA, Mohamed SK, Soliman AMM, Abd el-Ghanya H (2014) Synthesis of Dihydroimidazole Derivatives under Solvent Free Condition and Their Antibacterial Evaluation . Biochem Physiol 3:139. doi:10.4172/2168-9652.1000139
Copyright: © 2014 Ali El-Remaily MAEAA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Reaction of 2-guanidinobenzoxazole with several halogenated active methylene compounds has revealed formation of the corresponding dihydroimidazole derivatives under solvent free conditions in excellent yield. The anti-bacterial evaluation of the newly synthesized products against different types of Gram-positive and Gramnegative bacteria was performed. Most of products showed high inhibitory effect. The structure of all compounds has been characterized by on IR, 1H-NMR, 13C-NMR, Mass spectrum and some X-ray diffractions.

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