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Synthesis of Dox Drug Conjugation and Citric Acid Stabilized Superparamagnetic Iron-Oxide Nanoparticles for Drug Delivery | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Research Article

Synthesis of Dox Drug Conjugation and Citric Acid Stabilized Superparamagnetic Iron-Oxide Nanoparticles for Drug Delivery

Pramod Kumar*, Shrish Agnihotri and Indrajit Roy
Department of Chemistry, University of Delhi, Delhi-110007, India
Corresponding Author : Pramod Kumar
Department of Chemistry, University of Delhi, Delhi-110007, India
Tel: +91-9711065966
E-mail: [email protected]
Received: December 10, 2015; Accepted: January 06, 2016; Published: January 13, 2016
Citation: Kumar P, Agnihotri S, Roy I (2016) Synthesis of Dox Drug Conjugation and Citric Acid Stabilized Superparamagnetic Iron-Oxide Nanoparticles for Drug Delivery. Biochem Physiol 5:194. doi:10.4172/2168-9652.1000194
Copyright: © 2016 Kumar P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In this manuscript, we report a novel, low cost and easy synthesis, iron-oxide nanoparticles were synthesized via room-temperature reduction of a mixture of ferric and ferrous salts, containing citric acid as capping agent. Next, anticancer drug doxorubicin (Dox) was used to form electrostatic conjugation with these nanoparticles. The resulting drug-nanoconjugates were characterized for their size, composition, functionality, crystallinity, along with their magnetic and optical behavior. Following that, they were treated with cultured lung carcinoma cell lines (A 549) to probe their non-toxicity and biocompatibility. Concurrently, their uptake in cells in culture was studied by optical bioimaging. In vitro studies have shown that these nanoparticles are nontoxic (using MTT assay) to cells in culture.

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